Ramipex 0.25/Ramipex 1 Dosage/Direction for Use

General Dosing Considerations: Pramipexole tablets are taken orally, with or without food.
If a significant interruption in therapy with pramipexole tablets have occurred, retitration of therapy may be warranted.
Dosing in Patients with Normal Renal Function: Initial Treatment: Doses should be increased gradually from a starting dose of 0.375 mg/day given in three divided doses and should not be increased more frequently than every 5 to 7 days. A suggested ascending dosage schedule that was used in clinical studies is shown in Table 1 (see Table 1):

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Maintenance Treatment: Pramipexole is effective and well tolerated over a dosage range of 1.5 to 4.5 mg/day administered in equally divided doses three times per day with or without concomitant levodopa.
When pramipexole tablets are used in combination with levodopa, a reduction of the levodopa dosage should be considered.
Dosing in Patients with Renal Impairment: The recommended dosing of pramipexole in Parkinson's disease patients with renal impairment is provided in Table 2. (See Table 2.)

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Discontinuation of Treatment: Pramipexole may be tapered off at a rate of 0.75 mg per day until the daily dose has been reduced to 0.75 mg. Thereafter, the dose may be reduced by 0.375 mg per day.
Or as prescribed by the physician.